Biliverdin reductase: a target for cancer therapy?
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چکیده
منابع مشابه
Biliverdin reductase: a target for cancer therapy?
Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways. Activation of certain kinases in these pathways is/are hallmark(s) of cancerous cells. The protein is a scaffold/bridge and intracellular transporter of kinases that regulate growth and proliferat...
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A heme (Fe-porphyrin complex) is a prosthetic group of hemoproteins such as hemoglobin, myoglobin, cytochromes and so on. In biological systems, the heme is decomposed by two enzymes (hemeoxygenase and biliverdin reductase) and excreted (Fig. 1). Biliverdin reductase (BVR) catalyzes the last step of the heme catabolism, in which the biliverdin is reduced into bilirubin with two electrons from N...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2015
ISSN: 1663-9812
DOI: 10.3389/fphar.2015.00119